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A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorder. BDNF is widely distributed in various regions of the brain, and aids in survival, support and function of neurons. Loss of a beneficial activity of wild-type huntingtin may also cause the death of striatal neurons, leading to the development of Huntington's disease. Thomas K, Davies A. The BDNF expression levels are low during fetal development, markedly increase after birth, and then decrease in adults [ 17 — 19 ]. BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. B W Lloyd and A Oto.

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National Center for Biotechnology InformationU.

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Brain-derived neurotrophic factor and its clinical implications

Decreased levels of BDNF are associated with neurodegenerative diseases with neuronal loss, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis and Huntington's disease. Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival. BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. Mast cells synthesize, store, and release nerve growth factor. The activation of TrkB is the quickest event 2 minand deactivation occurs within 30 min after activation in the spinal cord [ 20 ].

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