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Controlling the false discovery rate: In some regions there appeared to be converse differences: Global status and trends, drivers and consequencesp. Retrieved from " https: Here, we report a study that characterizes multimodal sex differences in the adult human brain in the largest sample to date.

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Insights into how and where the brain differs as a function of sex—with considerably more precision than in previous investigations—will enable more targeted examinations into potential drivers of these differences across psychiatric, psychological, and other domains.

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In addition, cross-sectional mediation models of observational data, such as those used here, are inherently limited: Resting-state fMRI analyses also revealed a global effect: On the topic of age adjustment, it should also be noted that we adjusted for linear effects of age, whereas some variables may have nonlinear trends although, given a preliminary analysis as described in the Supplemental Materialswe would not expect this to affect the sex differences in these variables to a substantial extent. Get Directions Book a table. P -values for brain variables corrected for multiple comparisons using the False Discovery Rate correction.

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